This is a special edition of the ORISE Featurecast, wherein host Michael Holtz interviewed the winners of the Ignite Off! competition during the ORISE National Postdoc Appreciation Week Symposium, held Wednesday, September 20. Amanda Fanelli de Souza, Madeline Addis and Samaria Estrella discuss their Ignite Off! presentations, the trajectories of their academic and research careers, obstacles they have faced as women in STEM, and the importance of mentorship and collaboration. The conversation was fun and, we hope, enlightening. Give it a listen. Learn more about the ORISE Ignite Off! here: https://orise.orau.gov/igniteoff/index.html